SuFEx reactions when shaken not stirred
Click reactions display many of the goals desired for more sustainable chemical conversions. Yet, the solvent used is an often overlooked aspect in determining the environmental impact of reactions. In the current paper we develop the first mechanochemical method for the efficient and solvent‐free SuFEx reaction of sulfonyl fluorides with a wide range of phenols. After outlining the optimization process, which yields an easy‐to‐use and robust method, we provide indications of the very wide scope of this approach, and demonstrate this potential via the application to a range of natural phenols that also display other functionalities, and several gram‐scale syntheses.
Authors
- Yaxin Wang (ORCID: https://orcid.org/0009-0009-2215-9825)
- Yumei Zhu (ORCID: https://orcid.org/0000-0003-4102-7923)
- Zitong Hao (ORCID: https://orcid.org/0009-0005-5255-531X)
- Han Zuilhof (ORCID: https://orcid.org/0000-0001-5773-8506)
- Yang Chao (ORCID: https://orcid.org/0000-0002-1383-1693)
- Sidharam P. Pujari
- Muhammad Islam
Institutions
- Tianjin University (CN)
- Muhammad Nawaz Sharif University of Engineering & Technology (PK)
- Wageningen University & Research (NL)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1002/adsc.202500254
- Citations
- 1
- Primary Topic
- Inorganic Fluorides and Related Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- National Science Foundation
- National Natural Science Foundation of China
- Jiaxing University
- Wageningen University and Research