Formulation and Evaluation of Solid Lipid Nanoparticle Loaded Mucoadhesive Thermoreversible Nasal In Situ Gel for Brain Targeting

The formulation and evaluation of solid lipid nanoparticles (SLNs) incorporated into mucoadhesive thermoreversible nasal in situ gels present a novel strategy for enhancing brain-targeted drug delivery.This review focuses on the development of this innovative system, highlighting the dual advantages of SLNs and mucoadhesive thermoreversible gels in optimizing therapeutic efficacy for central nervous system (CNS) disorders.We discuss the selection of suitable lipids, surfactants, and gelling agents, emphasizing their role in achieving desired physicochemical properties, such as particle size, stability, and drug release profiles.The mucoadhesive properties of the in situ gel facilitate prolonged retention in the nasal cavity, while the thermoreversible nature allows for easy application and enhanced patient compliance.The article also addresses the evaluation methodologies for assessing in vitro drug release, permeation studies, and in vivo brain targeting efficiency, providing insights into the mechanisms of action.Challenges related to formulation stability, toxicity, and regulatory considerations are critically examined, along with potential solutions.Finally, this review outlines future perspectives in the field, aiming to underscore the significance of SLN-loaded mucoadhesive thermoreversible nasal in situ gels as a promising avenue for targeted CNS therapies.