Unleashing Nootkatone: A Comprehensive Exploration of its Chemistry and Applications in Industry

Nootkatone is a chemical constituent of essential oil that can be extracted from many natural and synthetic sources, including grapefruit and Citrus paradise Macfadyen.Citrus grandis, vetiver grass, grapefruit, Callitropsis nootkatensis, pummelo, and Chrysopogon zizanioides are examples of natural plant sources.There may be more plant sources as well.Nootkatone that is synthesized finds widespread application in the culinary, cosmetic, and medicinal sectors.Recently, nootkatone was shown to be toxic to arthropods, and specifically against ticks.The ability of natural products to kill arthropods at relatively low concentrations represents an alternative to the use of synthetic pesticides for the control of disease vectors.As a result, there may be an opportunity to create novel tick management solutions that tackle important issues related to both urban and rural settings.Nootkatone is a naturally occurring sesquiterpene that is derived from valencene and found in plant matter and citrus oils like orange and grapefruit.It has been shown to have additional bioactivities, such as pesticidal and insecticidal properties.The nontoxic substance is approved for use in food, cosmetics, and pharmaceuticals, and is a new weapon against insect-borne diseases like Lyme disease and malaria, repelling and killing ticks and mosquitoes.It is approved in several countries for use as a flavour in foods, fragrances, drinks, and personal care products.The high cost of nootkatone when extracted from grapefruit is a major concern.Thus, the present review will focus on the natural insecticide nootkatone, its chemistry, and various industrial applications.