Aminoisothiazolamides, a new class of potent inhibitors of lysyl‐<scp>tRNA</scp> synthetase
The observed toxicological effects paired with the anticipated likelihood to overcome this problem, owing to the highly conserved active sites in different species, finally resulted in the conclusion to stop the further exploration of the otherwise promising class of herbicidal aminoisothiazolamides. Thus, we opted to discard several further herbicidal lead structures before the start of in-depth investigations when sequence analyses suggested similar levels of conservation between the respective binding pockets in plants and mammalians. © 2025 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Authors
- Olaf Peters
- Guido Bojack
- Jens Frackenpohl (ORCID: https://orcid.org/0000-0003-3457-0290)
- Bernd Laber (ORCID: https://orcid.org/0000-0003-2955-0746)
- Birgit Bollenbach‐Wahl
- Luke R. Churchman (ORCID: https://orcid.org/0000-0001-6077-9982)
- Jörg Freigang (ORCID: https://orcid.org/0000-0001-7120-3372)
- David M. Barber (ORCID: https://orcid.org/0000-0001-9906-1695)
- Stephanie J. Lee (ORCID: https://orcid.org/0000-0003-2600-6390)
- Claudia Hartfiel
- Jullien Rey
- Gudrun Lange
- Tyler Fahrenhorst‐Jones (ORCID: https://orcid.org/0000-0002-8461-774X)
- Marc Mosrin
- Caroline Hilmi (ORCID: https://orcid.org/0000-0002-4722-5667)
- Uwe Döller
- Anna M. Reingruber
- Karen Tilmant
- Shaun Rees (ORCID: https://orcid.org/0000-0001-7329-6840)
- China M. Payne (ORCID: https://orcid.org/0000-0001-7031-8397)
- Elmar Gatzweiler
- David Bernier (ORCID: https://orcid.org/0000-0002-3867-6503)
- Luka Posa (ORCID: https://orcid.org/0009-0009-5364-4444)
- Thomas Müller (ORCID: https://orcid.org/0009-0001-5422-3053)
- Yoann Huet
- Virginie Lempereur
- Jörg Tiebes
Institutions
- Bayer (France) (FR)
- Bayer (Germany) (DE)
Publication Details
- Journal
- Pest Management Science
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1002/ps.8759
- Primary Topic
- RNA and protein synthesis mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00