Development and Method Validation of Lumateperone by UV spectroscopy and Forced Degradation Study

Simple, precise, accurate and economical UV Spectrophotometric method have been developed for Lumateperone an Atypical Antipsychotic Drug approved for treatment of bipolar disorder and schizophrenia.Less expensive solvent like methanol is used for method validation study.Method validation study was done using UV-VIS spectrophotometer (make-Shimadzu) at 243.00 nm wavelength.Drug Lumateperone obeyed Beer-Lambert's law.Drug concentration ranges from 5g/ ml-45g/ ml were selected for study.Coefficient of correlation was found to be 0.9999, precision of method with RSD% of 0.145797, accuracy of method with 99.525 recovery, LOD is 0.315 and LOQ is 0.964.Lumateperone was subjected to forced degradation under different condition as per ICH guidelines.The sample generated was used for degradation studies using developed method.