Proteomic Changes Associated With Endogenous <i>FBXW7</i> Mutations in Moderately Differentiated Endometrial Cancer Cells Include Increased <scp>TROP2</scp> and Galectin‐3 Levels
This study provides novel insights into the proteomic and phosphoproteomic effects of the endogenous FBXW7<sup>-R367X</sup> and FBXW7<sup>-R505C</sup> mutations in EC cells, including increased levels of galectin-3, a potentially druggable target, and of TROP2, which is a druggable target in EC.
Authors
- Suresh Kumar Chalapareddy (ORCID: https://orcid.org/0000-0003-0107-9155)
- Daphne W. Bell (ORCID: https://orcid.org/0000-0001-7314-3932)
- Mary Ellen Urick (ORCID: https://orcid.org/0000-0002-1032-504X)
- Eun‐Jeong Yu (ORCID: https://orcid.org/0000-0002-2118-2128)
Institutions
- National Institutes of Health (US)
- National Human Genome Research Institute (US)
- Cancer Genetics (United States) (US)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/cam4.70765
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health