Cold‐induced fibrosis and metabolic remodeling in the turtle (<i>Trachemys scripta</i>) ventricle
By defining the structural and metabolic underpinnings of the cold-induced remodeling response in the turtle heart, we show commonalities between metabolic and fibrotic triggers of pathological remodeling in human cardiac disease. We propose the turtle ventricle as a novel model for studying the mechanisms underlying fibrotic and metabolic cardiac remodeling.
Authors
- Gina L. J. Galli (ORCID: https://orcid.org/0000-0002-1023-915X)
- Peter Gardner (ORCID: https://orcid.org/0000-0003-4034-3764)
- Dane A. Crossley (ORCID: https://orcid.org/0000-0001-9683-7013)
- Alex Henderson (ORCID: https://orcid.org/0000-0002-5791-8555)
- Janna L. Crossley
- J. C. McConnell (ORCID: https://orcid.org/0000-0001-9412-1644)
- John J. Mackrill
- Michael J. Sherratt (ORCID: https://orcid.org/0000-0003-4759-6617)
- A. Keen (ORCID: https://orcid.org/0000-0002-2187-5282)
- Holly A. Shiels (ORCID: https://orcid.org/0000-0001-5223-5205)
- John Marrin
- Alex J. Holsgrove
Institutions
- University of North Texas (US)
- University College Cork (IE)
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- Henry Royce Institute (GB)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1111/apha.70026
- Citations
- 1
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Biotechnology and Biological Sciences Research Council