Widespread antibiotic heterotolerance in bacteria remains undetected by resistance assays
Despite global efforts, antimicrobial resistance persists. Mechanisms like heterotolerance further undermine antibiotic effectiveness. Testing > 1000 clinical strains revealed widespread heterotolerance largely missed by conventional MIC-based diagnostics. Since AMR alone does not predict treatment success, new tests and strategies incorporating tolerance data are urgently needed to significantly improve patient outcomes.
Authors
- Laure Verstraete (ORCID: https://orcid.org/0000-0002-1819-9906)
- Philip Ruelens (ORCID: https://orcid.org/0000-0003-1524-1897)
- Linda De Vooght (ORCID: https://orcid.org/0000-0002-8425-8601)
- Laurence Van Moll
- Jan Michiels (ORCID: https://orcid.org/0000-0001-5829-0897)
- Bram Van den Bergh (ORCID: https://orcid.org/0000-0003-4429-9780)
- Nele Geerts
- Natalie Verstraeten (ORCID: https://orcid.org/0000-0002-9548-4647)
- Paul Cos (ORCID: https://orcid.org/0000-0003-4361-8911)
- Sang D. Nguyen
- Lieze Agten
Institutions
- University of Antwerp (BE)
- Vlaams Instituut voor Biotechnologie (BE)
Publication Details
- Journal
- Drug Resistance Updates
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1016/j.drup.2025.101239
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00