Free water imaging reveals asynchronous dopaminergic degeneration in substantia nigra and ventral tegmental area in prodromal and early Parkinson's disease
The present findings revealed a desynchronized degeneration pattern between the VTA and SNc, with no degeneration observed in the prodromal phase but gradual changes over time, leading to pronounced VTA degeneration in early PD. This underscores the impact of early VTA changes on PD symptoms, contributing to understanding of PD pathophysiology.
Authors
- Guofeng Shen (ORCID: https://orcid.org/0000-0002-7731-5399)
- Xianchang Zhang
- Yu Shen (ORCID: https://orcid.org/0000-0003-4862-1212)
- Wei Wei (ORCID: https://orcid.org/0000-0002-7566-2995)
- Ningli Wang (ORCID: https://orcid.org/0000-0002-8933-4482)
- Xinhui Wang (ORCID: https://orcid.org/0000-0002-2341-8720)
- Meiyun Wang (ORCID: https://orcid.org/0000-0001-9920-9610)
- Yan Bai (ORCID: https://orcid.org/0000-0003-2421-4129)
- Neil Roberts (ORCID: https://orcid.org/0000-0001-5538-8653)
- Chenyao Sun (ORCID: https://orcid.org/0000-0002-2035-3888)
- Xiaosheng Song
- Keyang Ding
Institutions
- Shanghai Medical Information Center (CN)
- Henan Academy of Sciences (CN)
- Henan Provincial People's Hospital (CN)
- Siemens Healthcare (United States) (US)
- The Queen's Medical Research Institute (GB)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111309
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78