F-box protein FBXO21 overexpression inhibits the proliferation and metastasis of clear cell renal cell carcinoma and is closely related to the CREB pathway and tumor immune cell infiltration
These results suggest that FBXO21 is a novel prognostic biomarker for ccRCC patients and functions as a tumor suppressor gene. Moreover, FBXO21 may regulate the CREB pathway and is closely related to tumor immune cell infiltration in ccRCC.
Authors
- Minghao Lu (ORCID: https://orcid.org/0000-0002-0062-7861)
- Wuping Yang (ORCID: https://orcid.org/0000-0001-7608-1191)
- Peng Ding (ORCID: https://orcid.org/0000-0002-6348-9531)
- Dan Xia (ORCID: https://orcid.org/0000-0002-5256-3900)
- Cunjin Wu
- Taile Jing (ORCID: https://orcid.org/0000-0002-0294-5652)
Institutions
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1186/s12967-025-06356-y
- Citations
- 2
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China