Development of a Potential Bone-Seeking Radiopharmaceutical by Sodium Pyrophosphate Labeled <sup>188</sup>Rhenium (<sup>188</sup>Re-PYP) for Bone Pain Palliation
The present study investigated the initial labeling efficiency of <sup>188</sup>Re-PYP along with its biodistribution and in vitro stability. The <sup>188</sup>Re-PYP conjugate, prepared under optimized conditions, demonstrated radiochemical purity and stability. The biodistribution of the compound in mice exhibited high affinity for bone, whereas the complex was eliminated through the kidneys.
Authors
- Mostafa Moradi Sarabi (ORCID: https://orcid.org/0000-0003-3052-6858)
- B. Moghaddam (ORCID: https://orcid.org/0000-0002-0046-0731)
- Fariba Johari Daha (ORCID: https://orcid.org/0000-0002-4395-941X)
- Mehdi Salehi Barough
- Sahar Rajabi-Moghadam
Institutions
- Atomic Energy Organization of Iran (IR)
- Islamic Azad University Central Tehran Branch (IR)
- Nuclear Science and Technology Research Institute
Publication Details
- Journal
- Iranian journal of pharmaceutical research
- Published
- 2025-03-09
- DOI
- https://doi.org/10.5812/ijpr-153691
- Citations
- 1
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36