Long-Lasting Emollient and Anti-Itching Efficacy of a Creamy Rinse-Off Product Containing Purified Omental Lipids and A 3-Calm Anti-Itching Complex In The Treatment Of Xerosis: A Real-Life Trial on 171 Subjects

Background: Xerosis is caused by several diseases, including atopic dermatitis, and is characterized by a damaged skin barrier, leading to dryness, flakiness, and increased susceptibility to irritation but it's also related to drastically changes in keratinization and skin lipid content [1,2].A common symptom in xerosis patients is the development of pruritus, characterized by itching areas of dry skin.Numerous conventional detergents used in everyday life, are formulated with harsh chemicals and synthetic additives that can disrupt the skin's natural barrier, leading to increased dryness and irritation, predisposing to develop conditions such as xerosis [3].Study Aim: In this Real-Life study we wanted to evaluate the efficacy of a detergent (POL Calm detergente Cantabria Labs Difa Cooper, Caronno P, Italy) containing Purified Omental Lipids, lipoprotein-based surfactants, Trealix and 3-Calm anti-itching Complex, to hydrate and reduce the itching in patients with xerosis.Pure Omental Lipids have been proved to have emollient and moisturizing actions on skin, in addition it exerts angiogenic properties due to its richness in VEGF (Vascular Endothelial Growth Factor).Study design: We performed a multicentric, real-life open prospective 4-weeks clinical trial.Subjects and Methods: A total of 171 patients (102 women and 69 men, mean age 56 21 years) were enrolled and instructed to apply the POL detergent once daily for the entire duration of the trial (4 weeks).Results: At baseline, the xerosis score for the upper body parts was recorded at 2.22 1.02.After 4 weeks of treatment with POL Calm detergent, this score decreased significantly to 0.51 0.66, reflecting a reduction of 76.8%.Similarly, the xerosis score for the lower body parts decreased from 2.56 0.98 at baseline to 0.67 0.68 after treatment, indicating a reduction of 74%.The pruritus intensity score for the upper body parts demonstrated a baseline value of 2.16 1.17, which decreased to 0.43 0.61 after 4 weeks, representing a substantial reduction of 80.2%.Similar reduction of itch score was observed for the lower body parts.The product was very well tolerated.Conclusion: In this real-life study conducted in a large sample of subjects with severe xerosis, the use of a creamy rinse-off detergent containing purified omental lipids and anti-itching complex has demonstrated potent emollient and anti-itching effects.