KMT2D Induces M1 Macrophage Polarization to Repress Non-small Cell Lung Cancer Progression via Transcription Activation of ITGAL
The KMT2D transcriptionally activated ITGAL to trigger M1 macrophage polarization, thereby delaying NSCLC progression. Our findings suggest KMT2D as a potential therapeutic target for NSCLC.
Authors
- Pengfei Jiang (ORCID: https://orcid.org/0000-0001-8996-2406)
- Wentao Wang (ORCID: https://orcid.org/0009-0000-6439-5329)
- Jie Yang (ORCID: https://orcid.org/0000-0003-4801-7162)
Institutions
- First People’s Hospital of Jingmen (CN)
- Jining Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- Iranian journal of pharmaceutical research
- Published
- 2025-03-08
- DOI
- https://doi.org/10.5812/ijpr-159395
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00