Association between Hemoglobin, Serum Calcium, IgE, and Vitamin D Status among Children

Introduction: Documentation of the association of Hypovitaminosis D with anaemia, serum calcium level and IgE in children was limited, especially in South-Asian population.This study was conducted to observe the association of vitamin D status with hemoglobin, serum calcium, and IgE in the children of Bangladesh.Aim of the study: The study aimed to explore the association of hemoglobin, serum calcium, and IgE with vitamin D status in infants and children in South-East region of Bangladesh.Methods: This was a cross-sectional observational study conducted at a pediatrics clinic in Chittagong Metropolitan City from July 2012 to December 2017.In this study, a total of 524 participants between the age of 0-18 years were included.Results: In this study, more than half (269, 51.3%) of the study subjects were in the 1-5 years preschool age group, followed by 5-10 years aged school children (171, 32.6%).Out of 524 study subjects, hypovitaminosis D (<20ng/dl) was noticed in more than half of the cases 265(50.57%)based on measurement of serum 25 (OH) D. Only 259 (49.42%) cases were found to be sufficient (20-100ng/ml).A significant negative association was observed between hemoglobin and vitamin D for serum calcium.A significant positive association was observed between hemoglobin and serum calcium findings with respect to serum IgE levels, and there was a significant negative association (-0.048) between Vitamin D and serum IgE levels. Conclusion:Hypovitaminosis D (<20ng/dl) prevails significantly among Infants and children of South-East region of Bangladesh.Hemoglobin and Vitamin D levels had a significant negative association with serum calcium.A significant negative association was also observed between Vitamin D levels and IgE levels, but serum IgE had a positive association with both hemoglobin and serum calcium.