Clusterin deficiency exacerbates cholestatic liver disease through ER stress and NLRP3 inflammasome activation
The absence of clusterin exacerbates ER stress and NLRP3 inflammasome activation in mice fed a DDC diet. Conversely, overexpression of clusterin suppresses these stress responses. Thus, clusterin deficiency is associated with an enhanced inflammasome response in the liver that is linked to upregulation of ER stress.
Authors
- So Hee Lee (ORCID: https://orcid.org/0000-0002-9005-3207)
- Byoung Kuk Jang (ORCID: https://orcid.org/0000-0002-8950-0866)
- Eugene Han (ORCID: https://orcid.org/0000-0002-3237-3317)
- Jae Seok Hwang (ORCID: https://orcid.org/0000-0002-1510-3534)
- Mi Kyung Kim (ORCID: https://orcid.org/0000-0001-5750-3598)
- Ji Yeon Park (ORCID: https://orcid.org/0000-0002-6178-7906)
- Hye Won Lee (ORCID: https://orcid.org/0000-0002-0303-4658)
- Hye-Young Seo
Institutions
- Keimyung University (KR)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1186/s13578-025-01376-z
- Citations
- 1
- Primary Topic
- Clusterin in disease pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.05