Patients with Allan‐Herndon‐Dudley Syndrome (<scp>MCT8</scp> Deficiency) Display Symptoms of Parkinsonism in Childhood and Respond to Levodopa/Carbidopa Treatment
AHDS is associated with childhood parkinsonism, which is linked with biochemical abnormalities of dopamine metabolism. It can be treated with l-dopa/carbidopa supplementation. However, further research is needed to elucidate the exact effect of MCT8 deficiency on dopamine metabolism. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Alessandro Prigione (ORCID: https://orcid.org/0000-0001-9457-1952)
- Nina‐Maria Wilpert (ORCID: https://orcid.org/0000-0001-9453-8335)
- Marie‐Thérèse Henke (ORCID: https://orcid.org/0000-0001-6572-1667)
- Roser Pons (ORCID: https://orcid.org/0000-0001-6749-1906)
- Andrea Dell’Orco (ORCID: https://orcid.org/0000-0002-3964-8360)
- M. Bauer (ORCID: https://orcid.org/0000-0002-3120-7405)
- Thomas Opladen (ORCID: https://orcid.org/0000-0003-4349-7662)
- Christiane Grolik
- Angela Hewitt (ORCID: https://orcid.org/0000-0001-6565-4011)
- Markus Schuelke (ORCID: https://orcid.org/0000-0003-2824-3891)
- Knut Brockmann (ORCID: https://orcid.org/0000-0001-6823-9091)
- Catharina Lange (ORCID: https://orcid.org/0000-0002-6745-8441)
- Annika Zink (ORCID: https://orcid.org/0000-0002-8489-6339)
- Angela M. Kaindl (ORCID: https://orcid.org/0000-0001-9454-206X)
- Heiko Krude (ORCID: https://orcid.org/0000-0002-1169-0348)
- Christian Furth (ORCID: https://orcid.org/0000-0001-7302-7886)
- Sabine Jung‐Klawitter (ORCID: https://orcid.org/0000-0001-8851-672X)
- Christina Reinauer (ORCID: https://orcid.org/0000-0002-3272-8691)
- Anna Tietze (ORCID: https://orcid.org/0000-0002-2601-9055)
- Stephan Menz
- Monika Wahle
- Stine Christ
Institutions
- Physikalisch-Technische Bundesanstalt (DE)
- National and Kapodistrian University of Athens (GR)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University of Rochester Medical Center (US)
- Humboldt-Universität zu Berlin (DE)
- Düsseldorf University Hospital (DE)
- Universitätsmedizin Göttingen (DE)
- Kliniken der Stadt Köln (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Heinrich Heine University Düsseldorf (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1002/mds.30152
- Citations
- 3
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- Deutsche Forschungsgemeinschaft
- Berliner Sparkassenstiftung Medizin
- Berlin Institute of Health