Benign Idiopathic Myoclonus: A New Clinical Entity?
We suggest a new phenotype of physiologic myoclonus, which might be called "benign idiopathic myoclonus." It is characterized by distal myoclonus with onset during adolescence and benign course, without requiring treatment. Clinically and neurophysiologically these jerky movements were compatible with cortical myoclonus in some patients. We were unable to establish any genetic causes in explored cases. This phenotype might represent a particular subgroup of physiologic myoclonus, to be substantiated in multicenter cohorts.
Authors
- Giorgia Sciacca (ORCID: https://orcid.org/0000-0002-1629-1282)
- Jan Willem J. Elting (ORCID: https://orcid.org/0000-0003-3991-7097)
- Marina A.J. Tijssen (ORCID: https://orcid.org/0000-0001-5783-571X)
- A.M. Madelein van der Stouwe (ORCID: https://orcid.org/0000-0001-9497-2019)
- Hendriekje Eggink (ORCID: https://orcid.org/0000-0002-7006-1672)
- Martje E. van Egmond (ORCID: https://orcid.org/0000-0003-2648-6937)
- Sterre van der Veen (ORCID: https://orcid.org/0000-0003-0698-2087)
Institutions
- University Medical Center Groningen (NL)
- University of Catania (IT)
- Ospedale G.F. Ingrassia (IT)
Publication Details
- Journal
- Movement Disorders Clinical Practice
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1002/mdc3.70039
- Primary Topic
- Glycogen Storage Diseases and Myoclonus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Teva Pharmaceutical Industries
- European Commission
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Ipsen
- European Regional Development Fund