Synthesis, Spectrometrical Characterization and Pharmacological Properties of Six Substituted Hydrazones with Carbonyl Compounds

Hydrazones are molecules that prevent the growth of several microbial and parasitic strains by inhibited the replication of DNA sequences due to their chelating properties of metal ions. They are well recognized for Antiparasitic, Antimicrobial, Antibacterial, Antiviral, Antitumoral, Antimalarial and Anticonvulsive activities. The aim of the current study is to synthesized novel substituted hydrazones of ketones and aromatic aldehydes and to study their antiparasitic activities against Trypanosoma brucei brucei parasite. Synthesized hydrazone derivatives have been confirmed by elemental analysis and HPLC method, SMHR, 1H and 13C NMR spectroscopy. Three hydrazones derivatives have been synthesized namely phenylhydrazones, 2,4-dinitrophenyl hydrazones and benzohydrazones. The antiparasitic properties of these molecules were evaluated on Trypanosoma brucei brucei. The derivatives from phenylhydrazones and benzohydrazones were showing more antiparasitic activity like benzophenone benzohydrazone (D3) and salicylaldehyde phenylhydrazone (B1) compounds, which exhibited moderate activity on Trypanosoma brucei brucei (IC50 = 19.49 μM; IC50 = 20.01 μM respectively). Cytotoxicity tests again the human noncancer fibroblast cell line (WI38) were carried out with selected synthesized compounds and it showed that the most compounds were active against Trypanosoma brucei brucei. As a result of these findings, hydrazones could be a promising route in the treatment of trypanosomiasis.