Exploring the Activation of the Keap1‐Nrf2‐<scp>ARE</scp> Pathway by <scp>PAHs</scp> in Children's Toys
This study provides the first assessment of the skin sensitization potential of these PAHs. The findings suggest that B[k]F, B[b]F and chrysene may pose a higher risk of skin sensitisation than previously thought. Additionally, the synergistic effects observed in mixtures highlight the importance of considering combined exposures when assessing PAH exposure risk.
Authors
- Christoph Wiedmer (ORCID: https://orcid.org/0000-0002-6416-9396)
- Christian Kersch
- Simone Schmitz‐Spanke (ORCID: https://orcid.org/0000-0002-0416-8236)
- Andrea Buettner (ORCID: https://orcid.org/0000-0002-6205-5125)
- Rasha Alsaleh (ORCID: https://orcid.org/0000-0001-7917-5935)
- Jonas Lauenstein
- Simon van de Weyer
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Anhalt University of Applied Sciences (DE)
- Fraunhofer Institute for Process Engineering and Packaging (DE)
Publication Details
- Journal
- Contact Dermatitis
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1111/cod.14792
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.00