Cardiotoxicity of breast cancer drug treatments
Breast cancer (BC) is a leading cause of cancer-related mortality among women worldwide. BC is regarded as a systemic disease. Consequently, the majority of BC patients undergo systemic therapy to reduce the risk of distant metastasis (DM) and associated mortality. Although systemic therapies improve patients' outcome, they are associated with significant side effects, particularly cardiotoxicity and cardiovascular complications. Such side effects vary significantly in severity and duration. Cardiotoxicity may remain undetected for years post-treatment until the symptoms of heart failure (HF) present in the patient, which can reduce life expectancy, quality of life, and even lead to death. Therefore, it is vital to investigate the cardiotoxic and cardiovascular risks of BC treatment regimens to identify patients who would benefit most from cardiac monitoring. As it stands, cardiotoxicity is reported from individual studies or for selected drug therapies only. This review fulfils a gap in the literature by combining clinical studies of cardiotoxicity together from clinical trial data published on clinicaltrials.gov.uk.
Authors
- Corinne L. Woodcock (ORCID: https://orcid.org/0000-0001-6369-0182)
- Emad A. Rakha (ORCID: https://orcid.org/0000-0002-5009-5525)
- Maria Haque
- Catrin S. Rutland (ORCID: https://orcid.org/0000-0002-2009-4898)
- Alexander Dean
- Melissa B. Davis (ORCID: https://orcid.org/0000-0002-6124-6923)
- Jennie N. Jeyapalan (ORCID: https://orcid.org/0000-0002-6133-224X)
- N Atallah (ORCID: https://orcid.org/0000-0001-6845-5608)
- Mansour Abdulaziz Alsaleem (ORCID: https://orcid.org/0000-0002-7689-2493)
- Sheeba Irshad (ORCID: https://orcid.org/0000-0002-4419-7162)
- Dhruvika Varun (ORCID: https://orcid.org/0000-0002-8364-2994)
- Nigel P. Mongan (ORCID: https://orcid.org/0000-0001-5438-1126)
- Anna E. Harris (ORCID: https://orcid.org/0000-0003-4153-1652)
- Rodhan Patke (ORCID: https://orcid.org/0000-0001-8318-2521)
- Jorja Jackson-Oxley (ORCID: https://orcid.org/0009-0007-1885-6818)
- Rachel L Thompson
- Cyntholia H Okui
Institutions
- University of Nottingham (GB)
- Qassim University (SA)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Cornell University (US)
- Institute of Mental Health (GB)
- Sunny BioDiscovery (United States) (US)
- Hamad Medical Corporation (QA)
- Morehouse School of Medicine (US)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1016/j.tranon.2025.102352
- Citations
- 5
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 6.94