Improving the Performance of Prenatal Cell‐Free DNA Screening Through Size‐Selective Fetal DNA Enrichment in a Cohort of 71,986 General and High‐Risk Pregnancies
Cell-free fetal DNA enrichment significantly improves the PPVs of common trisomies and CNVs in general and high-risk populations. It has the potential for the clinical application effect of cell-free DNA screening.
Authors
- Yanan Liu (ORCID: https://orcid.org/0000-0003-4244-7161)
- Weiqiang Liu (ORCID: https://orcid.org/0000-0002-2536-9176)
- Fengxiang Wei (ORCID: https://orcid.org/0009-0006-6324-8400)
- Xiaohang Chen
- Liang Hu (ORCID: https://orcid.org/0000-0002-4416-0546)
- Wen Liangzhen (ORCID: https://orcid.org/0000-0002-6368-1005)
- Jiatong Zhong
Institutions
- Shantou University (CN)
- Longgang Central Hospital (CN)
- Shenzhen Maternity and Child Healthcare Hospital (CN)
- Shantou University Medical College (CN)
Publication Details
- Journal
- Prenatal Diagnosis
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1002/pd.6775
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shenzhen City