Kinetic Study of Aquo-Ethylene Glycol on Alkali Catalyzed Hydrolysis of Heterocyclic Acid Ester Methylpicolinate and Thermodynamic Activation Parameters

A kinetic investigation was conducted to analyze the thermodynamic parameters of the hydrolysis of Methylpicolinate in water-Ethylene glycol solvent system, using different concentration of Ethylene glycol (v/V) at four different temperature 200C, 250C, 300C, and 350C. The influence of the solvent on the reaction rate was analyzed in terms of activation parameters. The decreasing trend in ΔH* and ΔS* values, coupled with the rising ΔG* with increasing concentration (mole %) of the organic co - solvent in the reaction media, inferred an enthalpy-dominated and entropy-controlled reaction. The evaluated value of Isokinetic temperature is very close to 300, suggesting the presence of weak but positive interaction between solvent and solute present in the reaction media