Post-resuscitation blood pressure management: Effects of different MAP targets on cerebral perfusion and inflammation in a porcine model
Our findings indicate that high MAP targets enhance cerebral perfusion but concurrently exacerbate neuroinflammation. The observed autoregulatory impairment appears to emerge as a delayed phenomenon following cardiac arrest and ROSC, rather than as a direct consequence of elevated MAP levels. These results underscore the need for individualized blood pressure management strategies post-ROSC, weighing the potential benefits of increased cerebral perfusion against the risk of neuroinflammation.
Authors
- Jens Kamuf (ORCID: https://orcid.org/0000-0003-2170-8510)
- Serge C. Thal (ORCID: https://orcid.org/0000-0002-1222-8729)
- Christoph Walter Jänig (ORCID: https://orcid.org/0000-0003-3550-1211)
- Karsten Sommer (ORCID: https://orcid.org/0000-0001-5904-7514)
- Muriel Paul (ORCID: https://orcid.org/0000-0002-0004-0286)
- Andreas García Bardon
- Tanghua Liu (ORCID: https://orcid.org/0000-0001-8382-9161)
- Alexander Ziebart (ORCID: https://orcid.org/0000-0002-0294-3884)
- Robert F. Kelm
- Petra Leukel
- Christian Breit
- Wolfgang Schreiber (ORCID: https://orcid.org/0000-0002-8827-1838)
- Willi Schmidbauer
- Victoria Albertsmeier
- Erik K. Hartmann
- Isra Hale
Institutions
- Johannes Gutenberg University Mainz (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Comprehensive Cancer Center Mainfranken (DE)
- Helios Universitätsklinikum Wuppertal (DE)
- Federal Office of Bundeswehr Equipment, Information Technology and In-Service Support (DE)
- Universitätsklinikum Würzburg (DE)
- Bundeswehrzentralkrankenhaus Koblenz (DE)
Publication Details
- Journal
- Resuscitation Plus
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1016/j.resplu.2025.100930
- Citations
- 1
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 2.25