Alzheimer’s disease neuropathological change in younger individuals with IDH-mutant glioma
Our study reveals an unexpectedly high prevalence of ADNC, particularly isolated pTau deposits, in the tumor-adjacent cortex of younger individuals with IDH-mutant glioma. These findings suggest tumor-driven tau accumulation, prompting further research into potential long-term cognitive effects.
Authors
- Adelheid Wöehrer (ORCID: https://orcid.org/0000-0001-8435-8189)
- Sigrid Klotz (ORCID: https://orcid.org/0000-0003-3096-2852)
- Bernhard Baumann (ORCID: https://orcid.org/0000-0001-6419-1932)
- Barbara Kiesel (ORCID: https://orcid.org/0000-0003-0939-9831)
- Lisa Greutter (ORCID: https://orcid.org/0009-0005-4801-4764)
- Yelyzaveta Miller-Michlits
- Georg Widhalm (ORCID: https://orcid.org/0000-0001-6014-0273)
- Lisa Schnitzenlehner
- Jessica Makoli
Institutions
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
- Hochschule Campus Wien (AT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/noajnl/vdaf057
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33