Frequent PD-L1 expression in oral squamous cell carcinoma of non-smokers and non-drinkers, and association of tumor infiltrating lymphocytes with favorable prognosis.
A large number of OSCC in NSND show PD-L1 expression (CPS ≥1). CD4 was a significant predictor for DFS and OS, in addition to the CD8/FoxP3 ratio being a near significant predictor for OS. The combination of frequent high CD8-positive TIL infiltrates in PD-L1-positive tumors makes NSND with OSCC in theory interesting candidates for treatment with immune checkpoint inhibitors.
Authors
- Mari F.C.M. van den Hout (ORCID: https://orcid.org/0000-0003-1120-5952)
- SM Willems
- F. Farshadpour
- Emma J. de Ruiter (ORCID: https://orcid.org/0000-0003-0369-8267)
- Frans J. Mulder
- Remco de Bree (ORCID: https://orcid.org/0000-0001-7128-5814)
- B. Kremer
- Ejm Speel
- Tfb Gielgens
Institutions
- University Medical Center Groningen (NL)
- Maastricht University Medical Centre (NL)
- Erasmus MC (NL)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- Amsterdam University Medical Centers (NL)
- Rijnstate Hospital (NL)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1016/j.tranon.2025.102357
- Citations
- 5
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 5.23
Funders
- Universiteit Maastricht
- Maastricht Universitair Medisch Centrum