Glucagon-like peptide-2 pharmacotherapy activates hepatic Farnesoid X receptor-signaling to attenuate resection-associated bile acid loss in mice
The data suggest that GLP-2-pharmacotherapy in mice significantly slows bile acid circulation primarily via hepatic Farnesoid X receptor-signaling.
Authors
- Alexander Cecil (ORCID: https://orcid.org/0000-0002-1430-1790)
- Bernd Joachim Krause (ORCID: https://orcid.org/0000-0002-2572-4131)
- Robert Jaster (ORCID: https://orcid.org/0000-0002-8220-4570)
- Cornelia Prehn (ORCID: https://orcid.org/0000-0002-1274-4715)
- Nagi Elleisy
- Sarah M. Schwarzenböck
- Nooshin Mohebali
- Georg Lamprecht (ORCID: https://orcid.org/0000-0003-0997-3135)
- Peggy Berlin (ORCID: https://orcid.org/0000-0001-8354-6970)
- Johannes Reiner
- Maria Witte (ORCID: https://orcid.org/0000-0001-6746-7260)
- Brigitte Vollmar (ORCID: https://orcid.org/0000-0002-2403-9597)
- Jens Kurth (ORCID: https://orcid.org/0000-0001-6864-4513)
- Tobias Lindner (ORCID: https://orcid.org/0000-0003-4010-3445)
- Robert H. Förster
- Jerzy Adamski
Institutions
- Helmholtz Zentrum München (DE)
- University of Rostock (DE)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1016/j.molmet.2025.102121
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Else Kröner-Fresenius-Stiftung
- Universität Rostock