PCSK6 ablation in blood circulating cells increases atherosclerotic burden, but improves plaque stability by activating Th17-smooth muscle cell modulatory axis
Global Pcsk6 ablation leads to the activation of both adaptive and innate immune systems. Interestingly, Pcsk6<sup>-/-</sup> ablation in bone marrow of hyperlipidemic mice revealed its dual role in atherogenesis, activating a Th17-SMC modulatory axis that promotes plaque stability, despite increased atherosclerotic burden.
Authors
- Roland Baumgartner (ORCID: https://orcid.org/0000-0003-1780-2424)
- Göran K. Hansson (ORCID: https://orcid.org/0000-0003-4148-5190)
- Daniel F.J. Ketelhuth (ORCID: https://orcid.org/0000-0002-0087-116X)
- Stephen Malin (ORCID: https://orcid.org/0000-0001-7723-9579)
- Bianca E Suur (ORCID: https://orcid.org/0000-0002-9143-1396)
- Anders Mälarstig (ORCID: https://orcid.org/0000-0003-2608-1358)
- Glykeria Karadimou (ORCID: https://orcid.org/0000-0002-4191-9369)
- Ljubica Matic (ORCID: https://orcid.org/0000-0002-7294-9667)
- Ulf Hedin (ORCID: https://orcid.org/0000-0001-9212-3945)
- Mariette Lengquist
- Anton Gisterå (ORCID: https://orcid.org/0000-0002-4614-8030)
- Otto Bergman (ORCID: https://orcid.org/0000-0003-4323-8150)
- Malin Kronqvist
- C Willems
Institutions
- Karolinska University Hospital (SE)
- University of Southern Denmark (DK)
- Aarhus University Hospital (DK)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Vascular Pharmacology
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1016/j.vph.2025.107490
- Citations
- 1
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.80