The effects of risperidone and voluntary exercise intervention on synaptic plasticity gene expressions in the hippocampus and prefrontal cortex of juvenile female rats

Risperidone affects synaptic plasticity through a complex mechanism in female juvenile rats: enhancing certain key genes in the hippocampus while inhibiting genes essential for mitochondrial function. In line with our hypothesis, voluntary exercise promotes genes beneficial for synaptic plasticity and enhances specific genes reduced by risperidone, in female juvenile rats.