Alterations in magnetic susceptibility correlate with higher cerebral blood flow in the right amygdala of patients with major depressive disorder
The magnetic susceptibility of the amygdala was higher in MDD patients with than in controls. QSM changes in the right amygdala correlated with increased CBF and worse depressed mood, indicating both microstructural and functional alterations. Our results encourage further use of the QSM technique in the elucidation of MDD pathophysiology.
Authors
- Qianyun Chen (ORCID: https://orcid.org/0000-0003-3129-8527)
- Yingwei Qiu (ORCID: https://orcid.org/0000-0003-1298-8506)
- Gangqiang Hou (ORCID: https://orcid.org/0000-0001-6420-3155)
- Yingli Zhang (ORCID: https://orcid.org/0009-0003-6608-5596)
- Zhifeng Zhou (ORCID: https://orcid.org/0009-0001-3911-8706)
- Hongyan Huang
Institutions
- Shenzhen Sixth People's Hospital (CN)
- ShenZhen People’s Hospital (CN)
- Shenzhen KangNing Hospital (CN)
- Jinzhou Kangning Hospital (CN)
- Shenzhen University Health Science Center (CN)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1016/j.jad.2025.03.070
- Citations
- 1
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.43