Targeting YBX1‐m5C mediates <i>RNF115</i> mRNA circularisation and translation to enhance vulnerability of ferroptosis in hepatocellular carcinoma
YBX1 inhibits ferroptosis in HCC by regulating the RNF115-DHODH axis. RNF115, an E3 ligase, mediates K27 ubiquitination and autophagic degradation of DHODH. YBX1 binds to the m5C sites of RNF115 mRNA 3'-UTR and interacts with EIF4A1 to bridge the 5'-UTR, promoting mRNA circularisation and translation. High expression of YBX1/RNF115 predicts the poor overall survival in HCC.
Authors
- Yan-Jia Guo
- Jingyao Wei (ORCID: https://orcid.org/0000-0002-8357-0898)
- Na Qin (ORCID: https://orcid.org/0009-0001-2399-3514)
- Ying Yang (ORCID: https://orcid.org/0000-0002-8104-5985)
- Yun‐Gui Yang (ORCID: https://orcid.org/0000-0002-2821-8541)
- Jia-sheng Dong
- Xiangyi Sun
- Xin Tian (ORCID: https://orcid.org/0000-0003-0392-6362)
- Lan Huang (ORCID: https://orcid.org/0000-0001-6200-2309)
- Yue Du (ORCID: https://orcid.org/0009-0003-5488-1499)
- Yong Shi
- Han Wang (ORCID: https://orcid.org/0000-0003-1247-9859)
- Xianbin Li (ORCID: https://orcid.org/0000-0002-9196-7027)
- Ke An (ORCID: https://orcid.org/0000-0002-3328-5802)
- Ranran Sun (ORCID: https://orcid.org/0000-0002-2085-6741)
- Quancheng Kan (ORCID: https://orcid.org/0000-0003-1467-2396)
- Yueqin Wang (ORCID: https://orcid.org/0000-0003-0408-6721)
- Ouwen Li
Institutions
- Beijing Institute of Genomics (CN)
- Zhengzhou University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/ctm2.70270
- Citations
- 16
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 12.90
Funders
- National Natural Science Foundation of China