NNMT promotes acquired EGFR-TKI resistance by forming EGR1 and lactate-mediated double positive feedback loops in non-small cell lung cancer
The combined contribution of these two positive feedback loops promotes EGFR-TKI resistance in NSCLC. Our findings provide new insight into the role of histone methylation and histone lactylation in TKI resistance. The pivotal NNMT-mediated positive feedback loop may serve as a powerful therapeutic target for overcoming EGFR-TKI resistance in NSCLC.
Authors
- Jun Su (ORCID: https://orcid.org/0000-0002-4524-7168)
- Tianyu Qu (ORCID: https://orcid.org/0000-0002-4242-0615)
- Xiyi Lu (ORCID: https://orcid.org/0000-0003-2204-2052)
- Erbao Zhang (ORCID: https://orcid.org/0000-0002-5752-7976)
- Renhua Guo (ORCID: https://orcid.org/0000-0003-4475-8617)
- Liang Han (ORCID: https://orcid.org/0000-0003-3578-2914)
- Wei Li (ORCID: https://orcid.org/0000-0002-9991-7892)
- Dandan Yin
- Pingping Wu (ORCID: https://orcid.org/0000-0002-2587-7007)
- Jiali Dai (ORCID: https://orcid.org/0000-0003-4509-1391)
- Chang Zhang (ORCID: https://orcid.org/0000-0002-5443-8951)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Xuzhou Medical College (CN)
- XinHua Hospital (CN)
- Jiangsu Cancer Hospital (CN)
- Xuzhou Central Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1186/s12943-025-02285-y
- Citations
- 37
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 56.18