NLRP4 unlocks an NK/macrophages-centered ecosystem to suppress non-small cell lung cancer
Altogether, we delineated NLRP4's unexplored facets and discovered an NLRP4-driven anti-tumor ecosystem composed of TIGIT<sup>+</sup>TNFA<sup>+</sup> NK and iNOS<sup>+</sup> M1. Finally, targeting PP2A by its inhibitor successfully mimicked the anti-tumor capacity of the overexpression of NLRP4.
Authors
- Shun Lü (ORCID: https://orcid.org/0000-0001-8833-7262)
- Wenqing Lü (ORCID: https://orcid.org/0000-0003-0197-1653)
- Zhouwenli Meng
- Xiaomin Niu (ORCID: https://orcid.org/0000-0003-1079-1785)
- Ying Wang (ORCID: https://orcid.org/0000-0002-1407-2668)
- Yi Yang (ORCID: https://orcid.org/0000-0001-9044-0277)
- Jian Li (ORCID: https://orcid.org/0000-0002-0864-5108)
- Hui Wang (ORCID: https://orcid.org/0000-0003-2791-8981)
- Zhengqi Cao (ORCID: https://orcid.org/0000-0001-6323-8903)
- Ziming Li (ORCID: https://orcid.org/0009-0005-5718-2145)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Chest Hospital (CN)
Publication Details
- Journal
- Biomarker Research
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s40364-025-00756-4
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- National Natural Science Foundation of China