2069 The Association of Patient Reported Outcomes and Cerebrovascular Reactivity Following Moderate and Severe TBI: A Prospective Cohort Study

INTRODUCTION: Global clinical outcomes are known to be associated with dysfunctional cerebrovascular reactivity (CVR) following traumatic brain injury (TBI). However, the association of CVR in the acute and chronic phase of injury with patient-reported health-related quality of life (HRQOL) metrics has never been explored. METHODS: In this prospective cohort study, the association between continuous acute and chronic phase CVR with patient reported HRQOL outcomes following moderate and severe TBI was examined for the first time. The main outcomes of interest of this study were validated measures of patient-reported HRQOL over various domains as measured by the 12-Item Short-Form Health Survey (SF-12). RESULTS: In a cohort of 29 TBI patients, acute phase CVR was found to be significantly more active in those with a favorable Mental Component Summary (MCS) score of the SF-12 at early follow-up when measured by COx and COx_a. Further, multivariable logistic regression analysis found acute phase COx and COx_a to improve model performance when predicting favorable versus unfavorable early MCS scores over established prognostic model parameters. CONCLUSIONS: This is the first ever study to identify a relationship between acute phase CVR following moderate-to-severe TBI with mental and cognitive outcomes as experienced by patients. Further examination of the role dysfunctional CVR may play in mental and cognitive outcomes following TBI is needed.