Insulin resistance-induced mitochondrial dysfunction and pyroptosis in trophoblasts: protective role of metformin
IR, independent of hyperglycemia, drives placental inflammation and trophoblastic injury via pyroptosis. Targeting the ROS/TXNIP/NLRP3 pathway with metformin or other therapeutic agents offers potential therapeutic value in managing IR-related complications in GDM.
Authors
- Na Wu (ORCID: https://orcid.org/0009-0000-1792-1197)
- Runyu Du (ORCID: https://orcid.org/0000-0002-7460-4734)
- Yu Bai (ORCID: https://orcid.org/0000-0002-2737-6038)
- Ling Li (ORCID: https://orcid.org/0000-0002-0087-3034)
- Ying Shao (ORCID: https://orcid.org/0000-0002-3929-3459)
Institutions
- China Medical University (CN)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1186/s12884-025-07419-0
- Citations
- 5
- Primary Topic
- Neonatal Health and Biochemistry
- Type
- article
- Field-Weighted Citation Impact
- 17.47
Funders
- National Natural Science Foundation of China