An improved method of transducing retinal ganglion cells using AAV via transpupillary injection in adult mouse eyes.
Transpupillary intravitreal injection reduces the potential risk compared to the transscleral approach, offering a promising and efficient method for delivering reporter genes to RGCs and ensuring high levels of gene expression without damage to the lens or retina.
Authors
- Su-Ting Lin (ORCID: https://orcid.org/0009-0000-6693-5210)
- Eldon E. Geisert (ORCID: https://orcid.org/0000-0003-0787-4416)
- Jeffrey H. Boatright (ORCID: https://orcid.org/0000-0001-5875-492X)
- Micah A. Chrenek (ORCID: https://orcid.org/0000-0002-1366-5963)
- Jana T Sellers (ORCID: https://orcid.org/0000-0002-8495-1369)
- Jiaxing Wang (ORCID: https://orcid.org/0000-0002-3981-6969)
- Fang‐Yu Lin
- John M. Nickerson (ORCID: https://orcid.org/0000-0003-2419-9897)
Institutions
- Emory University (US)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Glaucoma Research Foundation
- Research to Prevent Blindness
- Emory University
- National Institutes of Health