Viral expression of NE/PPE enhances anti-colorectal cancer efficacy of oncolytic adenovirus by promoting TAM M1 polarization to reverse insufficient effector memory/effector CD8+ T cell infiltration
In summary, this study presents the development of the novel oncolytic adenoviruses ADV<sup>NE</sup> and ADV<sup>PPE</sup> with enhanced anti-tumor efficacy and provides an in-depth exploration of their specific anti-tumor mechanisms. These findings indicate promising clinical therapeutic prospects and offer new insights for advancing oncolytic adenovirus therapies.
Authors
- Chunping Jiang (ORCID: https://orcid.org/0000-0002-5191-4000)
- Linpei Wang
- Junhua Wu (ORCID: https://orcid.org/0000-0003-4753-2648)
- Huawei Cui
- Ciliang Guo
- Xiaosong Gu (ORCID: https://orcid.org/0000-0002-2562-6275)
- Yuxin Zhang (ORCID: https://orcid.org/0000-0001-7224-2533)
- Shuo Wang (ORCID: https://orcid.org/0000-0002-0990-639X)
- Yan Zhuang (ORCID: https://orcid.org/0000-0002-8269-7520)
- Lingkai Kong (ORCID: https://orcid.org/0009-0002-0972-1202)
Institutions
- Fujian Medical University (CN)
- Nanjing Drum Tower Hospital (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s13046-025-03358-y
- Citations
- 22
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 39.98
Funders
- National Natural Science Foundation of China