Orientin alleviates chondrocyte senescence and osteoarthritis by inhibiting PI3K/AKT pathway
Orientin improves mitochondrial homeostasis, inhibits chondrocyte senescence, and alleviates OA progress via the PI3K/AKT/NF-κB axis, which suggests that orientin is a potential effective therapeutic agent for OA.
Authors
- Yinxian Wen (ORCID: https://orcid.org/0000-0003-1826-3864)
- Jun Xing (ORCID: https://orcid.org/0000-0002-2685-6806)
- Haitao Chen (ORCID: https://orcid.org/0000-0001-9937-8676)
- Siyi Liu (ORCID: https://orcid.org/0000-0002-6733-3497)
- Liaobin Chen
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- Bone and Joint Research
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1302/2046-3758.143.bjr-2023-0383.r2
- Citations
- 12
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 20.02