Bioinformatics analysis, immunogenicity, and therapeutic efficacy evaluation of a novel multi-stage, multi-epitope DNA vaccine for tuberculosis
The W545 DNA vaccine effectively induces a Th1-type immune response, alleviates pathological damage, and demonstrates potential as an immunotherapeutic agent. Bioinformatics analysis provides valuable guidance for vaccine design and optimization.
Authors
- Yourong Yang (ORCID: https://orcid.org/0009-0005-9743-2188)
- Yong Xue (ORCID: https://orcid.org/0000-0002-9091-3772)
- Zaixing Jia (ORCID: https://orcid.org/0000-0003-1648-2430)
- Xiaoou Wang (ORCID: https://orcid.org/0000-0002-7040-5383)
- Xueqiong Wu (ORCID: https://orcid.org/0000-0001-8894-1929)
- Haimei Zhao (ORCID: https://orcid.org/0000-0001-8767-5251)
- Jinlei Guo (ORCID: https://orcid.org/0000-0002-4594-9696)
- Wenping Gong (ORCID: https://orcid.org/0000-0002-0333-890X)
- Nan Wang (ORCID: https://orcid.org/0000-0003-3338-7697)
- Lan Wang (ORCID: https://orcid.org/0000-0003-1369-0584)
- Jie Wang (ORCID: https://orcid.org/0000-0001-7870-0646)
- Fenghua Wang (ORCID: https://orcid.org/0000-0002-2443-8360)
- Xiao Li (ORCID: https://orcid.org/0000-0001-9420-9558)
- Yinping Liu (ORCID: https://orcid.org/0000-0002-1530-7692)
- Yan Liang (ORCID: https://orcid.org/0000-0002-7103-6428)
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1016/j.intimp.2025.114415
- Citations
- 3
- Primary Topic
- vaccines and immunoinformatics approaches
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Key Research and Development Program of China