Protein arginine methyltransferase 6 enhances immune checkpoint blockade efficacy via the STING pathway in MMR-proficient colorectal cancer
Our study provides a preclinical proof of concept to overcome resistance to immunotherapy by targeting PRMT6 in CRC with MSS.
Authors
- Jinlin Duan
- Yonglong Zhang (ORCID: https://orcid.org/0000-0001-6429-6304)
- Ting Lu (ORCID: https://orcid.org/0000-0001-8415-0185)
- Junyan Xue
- Tao Chen (ORCID: https://orcid.org/0000-0003-1543-607X)
- Yu Zhang (ORCID: https://orcid.org/0000-0003-1025-906X)
- Qiwei Li (ORCID: https://orcid.org/0000-0002-1020-3050)
- Ling Gao (ORCID: https://orcid.org/0000-0002-0091-2937)
- Yang Sun
Institutions
- Shanghai Jiao Tong University (CN)
- Soochow University (CN)
- Shanghai Ninth People's Hospital (CN)
- Tongren Hospital (CN)
- Shanghai First People's Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1136/jitc-2024-010639
- Citations
- 7
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Natural Science Foundation of China