Reprogramming of Intratumoral Neurons Supports Pancreatic Cancer Growth

Major Finding: Novel Trace-n-Seq technology reveals PDAC-mediated reprogramming of intratumoral neurons and increased connections with tumor cells and cancer-associated fibroblasts (CAF). Concept: Reprogrammed intratumoral neurons recruit CAFs to suppress immune cell infiltration.Impact: Denervation may augment the efficacy of immunotherapy or taxane-based chemotherapy in pancreatic cancer.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-027
Primary Topic
Neuroblastoma Research and Treatments
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Reprogramming of Intratumoral Neurons Supports Pancreatic Cancer Growth

Cancer Discovery
Neuroblastoma Research and Treatments
article

Reprogramming of Intratumoral Neurons Supports Pancreatic Cancer Growth

article en

Abstract

Major Finding: Novel Trace-n-Seq technology reveals PDAC-mediated reprogramming of intratumoral neurons and increased connections with tumor cells and cancer-associated fibroblasts (CAF). Concept: Reprogrammed intratumoral neurons recruit CAFs to suppress immune cell infiltration.Impact: Denervation may augment the efficacy of immunotherapy or taxane-based chemotherapy in pancreatic cancer.

Cancer Discovery
Good health and well-being
Openalex Percentile: Top 92%
Neuroblastoma Research and Treatments
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Reprogramming of Intratumoral Neurons Supports Pancreatic Cancer Growth · Cancer Discovery (2025) | TGRS Research Map | TGRS