Catalytic Atroposelective Electrophilic Amination to Access Axially Chiral Diaryl Phenols
An enantioselective synthesis of axially chiral diaryl phenols containing sulfonamide groups has been achieved involving an electrophilic amination of 1,1'-biaryl-2,6-diols with N-sulfonyl quinone diimines, catalyzed by a chiral phosphoric acid. This atroposelective reaction offers a modular approach to enantiopure diaryl phenols, with good-to-excellent yields.
Authors
- Jiangtao Sun (ORCID: https://orcid.org/0000-0003-2516-3466)
- Shengbiao Tang (ORCID: https://orcid.org/0000-0003-4860-5458)
- Ying Shao (ORCID: https://orcid.org/0000-0002-7379-8266)
- Qiang Chen (ORCID: https://orcid.org/0000-0002-2398-4482)
- Han Wang (ORCID: https://orcid.org/0000-0003-3882-4032)
Institutions
- Changzhou University (CN)
Publication Details
- Journal
- Chemistry - An Asian Journal
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1002/asia.202500239
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00