Identification of RSAD2 as a Key Biomarker Linking Iron Metabolism and Dendritic Cell Activation in Systemic Lupus Erythematosus Through Bioinformatics and Experimental Validation
Our findings suggest that <i>RSAD2</i> is a potential diagnostic biomarker and therapeutic target for SLE, elucidating the intricate relationship between immune dysregulation and aberrant iron metabolism in activated DCs, which exacerbates SLE.
Authors
- Sheng Gao (ORCID: https://orcid.org/0000-0002-8622-5694)
- Chunyan Hua (ORCID: https://orcid.org/0000-0001-7957-6106)
- Liangxing Wang (ORCID: https://orcid.org/0000-0002-7173-3581)
- Zhouhang Xing
- Lingjie Kong (ORCID: https://orcid.org/0000-0002-8250-7547)
- Yanggang Hong (ORCID: https://orcid.org/0009-0004-4507-0093)
- Hengrong Qian
- Ting Zhang (ORCID: https://orcid.org/0000-0001-5008-2081)
- Wenqian Wang (ORCID: https://orcid.org/0000-0003-2925-4306)
- Xinlei Wu
- Yiming Lin (ORCID: https://orcid.org/0000-0001-5903-4035)
- Yuanyuan Xie (ORCID: https://orcid.org/0000-0002-1019-5070)
- Anzhe Zheng
- Jintao Mo
- Siyan Chen
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/jir.s500115
- Citations
- 3
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 5.00