Effect and Mechanism of Aloin in Ameliorating Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Network Pharmacology and Experimental Verification
Our study revealed that Aloin exerts a beneficial effect on mitigating the pain symptoms associated with CP/CPPS, ameliorating inflammation, and reducing oxidative stress. Through network pharmacology, potential targets and signaling pathways were identified, suggesting the therapeutic promise of Aloin for CP/CPPS. These findings advocate for further exploration into its clinical efficacy and mechanistic underpinnings in the treatment of CP/CPPS.
Authors
- Zhilong Dong (ORCID: https://orcid.org/0000-0002-4919-8164)
- Chengyu You (ORCID: https://orcid.org/0000-0002-7692-9401)
- Liangliang Qing
- Yongfeng Lao (ORCID: https://orcid.org/0000-0002-6465-1115)
- Shuai Liu (ORCID: https://orcid.org/0000-0001-8732-9754)
- Rongxin Li (ORCID: https://orcid.org/0000-0001-5876-9355)
- Yanan Wang (ORCID: https://orcid.org/0000-0002-6685-9753)
- Qingchao Li (ORCID: https://orcid.org/0000-0002-0307-0085)
- Xin Guan (ORCID: https://orcid.org/0000-0001-7629-0591)
- Xiaolong Li (ORCID: https://orcid.org/0009-0006-9431-8336)
- Jian Wang
Institutions
- Gansu Meteorological Bureau (CN)
- Lanzhou University Second Hospital (CN)
- Gansu Provincial Center for Disease Control and Prevention (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/dddt.s473678
- Citations
- 2
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 3.11