Effective dose of ciprofol combined with low-dose sufentanil for sedation of gastroscopy: a dose-finding study using a biased coin design
The 90% effective dose of ciprofol combined with 5 µg of sufentanil for sedation during gastroscopy was determined to be 0.367 (95% CI: 0.344-0.416) mg/kg. Within the dose range of 0.3-0.45 mg/kg, ciprofol reduced the mean arterial pressure and heart rate in patients, but these effects were not dose-dependent.
Authors
- Chao Yu (ORCID: https://orcid.org/0000-0002-9244-9416)
- Bingwei Hu (ORCID: https://orcid.org/0000-0002-4484-5043)
- Qing Wang (ORCID: https://orcid.org/0000-0001-6540-1858)
- Hongwei Wang (ORCID: https://orcid.org/0000-0002-7849-6304)
- Ting Guan
- Danfeng Wang (ORCID: https://orcid.org/0009-0002-2059-3168)
Institutions
- Zhejiang Chinese Medical University (CN)
- Tongde Hospital of Zhejiang Province (CN)
Publication Details
- Journal
- BMC Anesthesiology
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s12871-025-02986-3
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00