Comparative analysis of deep learning architectures for breast region segmentation with a novel breast boundary proposal

Segmentation of the breast region in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is essential for the automatic measurement of breast density and the quantitative analysis of imaging findings. This study aims to compare various deep learning methods to enhance whole breast segmentation and reduce computational costs as well as environmental effect for future research. We collected fifty-nine DCE-MRI scans from Stavanger University Hospital and, after preprocessing, analyzed fifty-eight scans. The preprocessing steps involved standardizing imaging protocols and resampling slices to ensure consistent volume across all patients. Using our novel approach, we defined new breast boundaries and generated corresponding segmentation masks. We evaluated seven deep learning models for segmentation namely UNet, UNet++, DenseNet, FCNResNet50, FCNResNet101, DeepLabv3ResNet50, and DeepLabv3ResNet101. To ensure robust model validation, we employed 10-fold cross-validation, dividing the dataset into ten subsets, training on nine, and validating on the remaining one, rotating this process to use all subsets for validation. The models demonstrated significant potential across multiple metrics. UNet++ achieved the highest performance in Dice score, while UNet excelled in validation and generalizability. FCNResNet50, notable for its lower carbon footprint and reasonable inference time, emerged as a robust model following UNet++. In boundary detection, both UNet and UNet++ outperformed other models, with DeepLabv3ResNet also delivering competitive results.