Pharmacokinetics of betamethasone in pre‐eclampsia: An in vivo and ex vivo study
Women with early-onset pre-eclampsia have elevated betamethasone exposure. Betamethasone transfers freely into the foetal circulation, with placental metabolism resulting only in 11-ketobetamethasone. Decreased placental 11β-HSD1 expression may play a role in increased betamethasone exposure in early-onset pre-eclampsia.
Authors
- Letao Li (ORCID: https://orcid.org/0000-0002-4692-9689)
- Birgit C. P. Koch (ORCID: https://orcid.org/0000-0002-1202-3643)
- Emma Ronde (ORCID: https://orcid.org/0000-0001-9277-5361)
- Anna Kluivers (ORCID: https://orcid.org/0000-0002-4115-372X)
- Ron HN van Schaik (ORCID: https://orcid.org/0000-0003-1864-2151)
- Bertrand D. van Zelst (ORCID: https://orcid.org/0000-0001-9148-399X)
- Sam Schoenmakers (ORCID: https://orcid.org/0000-0002-0316-6159)
- A.H. Jan Danser (ORCID: https://orcid.org/0000-0002-5052-3585)
- Irwin Reiss (ORCID: https://orcid.org/0000-0002-9474-6895)
- Philip DeKoninck (ORCID: https://orcid.org/0000-0002-4457-0940)
- Sinno H. P. Simons (ORCID: https://orcid.org/0000-0001-5219-5696)
- Sjoerd A.A. van den Berg (ORCID: https://orcid.org/0000-0001-5937-7505)
- Michelle Broekhuizen (ORCID: https://orcid.org/0000-0002-4736-398X)
- Sebastiaan D. T. Sassen (ORCID: https://orcid.org/0000-0002-4525-638X)
- Karel Allegaert (ORCID: https://orcid.org/0000-0001-9921-5105)
- Madhavi S. Harhangi (ORCID: https://orcid.org/0000-0001-5814-1103)
Institutions
- Erasmus MC (NL)
- KU Leuven (BE)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1002/bcp.70035
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.06
Funders
- China Scholarship Council