Dual inhibition of MAPK and TORC1 signaling retards development of radiation resistance in pediatric <i>BRAF</i> <i>V600E</i> glioma models
PI3K-mTOR activation promotes the development of XRT resistance in pediatric BRAFV600E glioma. Dual targeting of MAPK and TORC1 signaling significantly enhances the therapeutic efficacy of XRT and can potentially prevent the development of XRT resistance.
Authors
- Siyuan Zheng (ORCID: https://orcid.org/0000-0002-1031-9424)
- Hanzhou Wang (ORCID: https://orcid.org/0000-0002-0493-827X)
- Amyn A. Habib (ORCID: https://orcid.org/0000-0003-4164-9028)
- Kathryn Bondra (ORCID: https://orcid.org/0000-0002-7261-3346)
- Bipasha Mukherjee (ORCID: https://orcid.org/0000-0001-5368-9276)
- Sandeep Burma (ORCID: https://orcid.org/0000-0001-7057-9845)
- Fuyang Li
- Peter J. Houghton (ORCID: https://orcid.org/0000-0002-2400-8184)
- Suman Kanji
- Dias Kurmashev
- Yidong Chen (ORCID: https://orcid.org/0000-0001-6806-2185)
Institutions
- The University of Texas at San Antonio Health Science Center (US)
- Urology San Antonio (US)
- Children's Hospital of San Antonio (US)
- Southwestern Medical Center (US)
- Children's Cancer Center (US)
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1093/neuonc/noaf068
- Citations
- 2
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.25