Dynamics of SERPINA3 in response to anthracycline treatment and cardiovascular dysfunction
Circulating SERPINA3 levels show dynamic changes in a population of patients with cancer, with an overall decrease following AnC. However, in patients that developed moderate CTRCD, SERPINA3 levels remained elevated. The potential of SERPINA3 dynamics as a biomarker for CTRCD, deserves validation in larger cohorts.
Authors
- Ward Heggermont (ORCID: https://orcid.org/0000-0002-5368-2223)
- Sébastien Anguille (ORCID: https://orcid.org/0000-0002-1951-6715)
- Hein Heidbüchel (ORCID: https://orcid.org/0000-0001-9301-8127)
- Matthias Bosman (ORCID: https://orcid.org/0000-0001-9102-5366)
- Emeline M. Van Craenenbroeck (ORCID: https://orcid.org/0000-0001-7686-2668)
- Laure-Anne Teuwen (ORCID: https://orcid.org/0000-0003-1690-8198)
- Hanne M. Boen (ORCID: https://orcid.org/0000-0001-7135-3178)
- Anke Verlinden (ORCID: https://orcid.org/0000-0002-0899-1772)
- Kirsten Saevels
- Pieter‐Jan Guns (ORCID: https://orcid.org/0000-0002-8640-6620)
- Caroline M. Van De Heyning (ORCID: https://orcid.org/0000-0002-4661-4732)
- Constantijn Franssen (ORCID: https://orcid.org/0000-0002-7085-5317)
- Lobke L. Pype (ORCID: https://orcid.org/0000-0002-9679-0996)
- Leen Delrue
- Sevilay Altıntaş
- Konstantinos Papadimitriou (ORCID: https://orcid.org/0000-0002-0059-2873)
Institutions
- University of Antwerp (BE)
- Onze Lieve Vrouwziekenhuis Hospital (BE)
- Antwerp University Hospital (BE)
Publication Details
- Journal
- Cardio-Oncology
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s40959-025-00324-7
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds Wetenschappelijk Onderzoek
- Koning Boudewijnstichting