Selective Oxidation of Tertiary Alcohols to Ketones via Synergistic Catalysis of (NH<sub>4</sub>)<sub>2</sub>Ce(NO<sub>3</sub>)<sub>6</sub> and Trifluoroacetic Acid With Oxygen
ABSTRACT Tertiary alcohols are generally considered difficult to oxidize. However, in this work, it was found that catalyzed by (NH 4 ) 2 Ce(NO 3 ) 6 (CAN) and in the presence of catalytic trifluoroacetic acid (TFA), the selective oxidative C‐C bond cleavage of tertiary alcohols could be achieved using O 2 flow to produce carbonyl compounds. The benefits of this method include the use of simple and inexpensive catalysts, as well as the environmentally friendly nature of the process. This research significantly broadens the scope of alcohol oxidation chemistry. Since alcohol oxidation reactions involving C‐C bond cleavage have potential applications as the key unit reaction in certain industrial processes, this finding holds significant promise for organic chemical engineering.
Authors
- Fenglin Chen (ORCID: https://orcid.org/0000-0001-6369-6998)
- Xinrui Xiao
- Hongwei Zhou (ORCID: https://orcid.org/0000-0001-8308-960X)
- Lei Yu (ORCID: https://orcid.org/0000-0001-5659-7289)
- Ying Chen (ORCID: https://orcid.org/0000-0001-9128-1837)
- Chao Chen (ORCID: https://orcid.org/0000-0002-4353-3283)
- Hongen Cao (ORCID: https://orcid.org/0000-0001-8686-4886)
- Xiaoxue Li (ORCID: https://orcid.org/0000-0003-3581-3442)
Institutions
- Kyushu Institute of Technology (JP)
- Jiaxing University (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- cMat
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/cmt2.35
- Citations
- 5
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- Yangzhou University
- Priority Academic Program Development of Jiangsu Higher Education Institutions