Rescue of loss‐of‐function long QT syndrome‐associated mutations in K<sub>V</sub>7.1/KCNE1 by the endocannabinoid N‐arachidonoyl‐L‐serine (ARA‐S)
This study demonstrates the rescuing capability of ARA-S on a diverse set of LQTS mutants. These insights may aid in developing drug compounds using ARA-S sites and mechanisms and guide interpretation of which LQTS mutants respond well to such compounds.
Authors
- Alicia de la Cruz (ORCID: https://orcid.org/0000-0002-0349-4881)
- Akshay Sridhar (ORCID: https://orcid.org/0000-0003-0633-7707)
- Julien Louradour (ORCID: https://orcid.org/0000-0002-0649-4975)
- Irene Hiniesto‐Iñigo
- Nina E. Ottosson (ORCID: https://orcid.org/0000-0003-2159-6731)
- Federica Giannetti (ORCID: https://orcid.org/0000-0002-1785-5529)
- H. Peter Larsson (ORCID: https://orcid.org/0000-0002-1688-2525)
- Luca Sala (ORCID: https://orcid.org/0000-0002-4129-6632)
- Sara I. Liin (ORCID: https://orcid.org/0000-0001-8493-0114)
- Katja E. Odening (ORCID: https://orcid.org/0000-0001-6999-841X)
- Siri Lundholm
- Amaia Jauregi‐Miguel (ORCID: https://orcid.org/0000-0003-0938-7734)
Institutions
- Linköping University (SE)
- University of Bern (CH)
- Science for Life Laboratory (SE)
- University Hospital of Bern (CH)
- IRCCS Istituto Auxologico Italiano (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1111/bph.70008
- Citations
- 2
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Vetenskapsrådet
- H2020 European Research Council